Since the beginning of the century, research using non-traditional stable (i.e., Li, B, Cu, Mo, Tl) and radiogenic (Sr, Pb, Nd) isotopes has been steadily expanding, thanks to significant advances in technologies, and a continuous effort from the scientific community to solve the numerous analytical challenges that come with this type of analysis.  In this workshop, a panel of experts will present a current picture of state-of-the-art isotope analytical methods, including key innovations in method development and novel field applications. Case studies will be presented demonstrating real world examples of application in mineral exploration and environmental monitoring, including exploration in covered terrains, characterization of key chemical reactions in mineral waste piles, or the tracking of environmental pollution through various media, to name a few. A discussion on the considerations that need to be considered to successfully use isotopes for mineral exploration and environmental monitoring will also be included, to provide the participants with all the information they need to include isotopes in their workflow and interpret the data generated.